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oVERVIEWPATIENT
CARERESEARCHEDUCATIONFACULTYCONTACTSHOME |
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Faculty Dennis T. Villareal, M.D. Dennis T. Villareal, M.D., has an interest in caring for older adults in a variety of settings. He has a geriatric assessment and endocrine clinic at the Center for Advanced Medicine. This clinic serves the frail older adult in the community that may have difficulty with dementia, medication issues, diabetes, nutrition problems, osteoporosis/falls, or depression. In 1997 Dr. Villareal established a Geriatric Consultation Service at Barnes-Jewish Hospital, which provides comprehensive assessment to high-risk older adults in the hospital setting. Dr. Villareal is an active participant in the training of health professionals at Washington University School of Medicine. Research Interests Trained in both geriatrics and endocrinology, Dr. Villareal has an interest in preventing frailty in obese and non-obese older adults. His research focuses on the potential role of lifestyle therapy, exercise training, and hormone replacement in reversing the aging process. He is investigating the effects of hormone replacement alone or in combination with exercise on outcomes such as physical function/frailty, bone density, glucose tolerance, lipids, strength, and quality of life. Dr. Villareal has studied both healthy elderly with a goal of preventing frailty, and frail older adults with a goal of preventing institutionalization. Contact Information Washington University School of Medicine Publications Recent Articles in Peer Reviewed Journals Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S. Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab 2008;93:2181-2187 Villareal DT, Banks M, Patterson B, Polonsky K, Klein S. Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity 2008;16: 1349-1354 Shah K, Wingkun NJ, Lambert CP, Villareal DT. Weight-loss therapy improves endurance capacity in obese older adults. J Am Geriatr Soc 2008;56:1157-1159 Frimel TN, Sinacore DR, Villareal DT. Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults. Med Sci Sports Exerc 2008;40:1213-1219 Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly J Appl Physiol 2008 [Epub ahead of print] Weiss, EP, Villareal DT, Racette SB, Steger-May K, Bhartur NP, Klein S, Fontana L. Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuven Res 2008; 11: 605-9 Fontana L, Villareal DT, Weiss EP, et al. Calorie restriction or exercise: effects on coronary heart disease risk factors. a randomized controlled trial. Am J Physiol Endocrinol Metab 2007;293:E197-202 Evans EM, Racette SB, Van Pelt R, Peterson LR, Villareal DT. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause 2007;14: 481-8 Smith G, Villareal DT, Mittendorfer B. Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer. Am J Physiol Endocrinol Metab 2007;293: E666-71. Weiss EP, Racette SB, Villareal DT et al. Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss J Appl Physiol; 2007; 102:634-640 Villareal DT, Fontana L. Weiss EP, et al, Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial Arch Int Med, 2006;166:2502-10 Villareal DT, Miller B, Banks M, Fontana L, Sinacore DR, and Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr, 2006;84:1317-23 Villareal DT, Holloszy JO. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006; 291:E1003-E1008 Villareal DT, Banks M, Sinacore DR, Siener
C, Klein S. Effect of weight loss and exercise on frailty in obese older
adults. Arch Int Med 2006;166;860-866
Department of Medicine
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