Faculty

Bruce Patterson, Ph.D.
Research Associate Professor in Medicine
Director, Clinical Research Science Core Laboratory for the Clinical Nutrition Research Unit

Research Interests

Dr. Patterson specializes in the application of stable isotope tracer methodology to the study of protein, fat, and carbohydrate metabolism in human subjects, and the application of mathematical modeling, particularly compartmental modeling, to studies of metabolic kinetics. Specific research interests include lipoprotein metabolism in obesity and the metabolic syndrome, and analysis of intravenous and oral glucose tolerance tests to determine insulin secretion rates and insulin sensitivity of glucose uptake.

Contact Information

Washington University School of Medicine
Center for Human Nutrition
660 S. Euclid Ave, Campus Box 8031
St. Louis, MO 63110 - 1093
Phone: (314) 747-1575
Fax: (314) 362-8230
e-mail: bpatters@wustl.edu

Publications

Recent Articles in Peer Review Journals

Bohlin, K.; Patterson, B.W.; Spence, K.L.; Merchak, A.; Zozobrado, J.C.G.; Zimmerman, L.J.I.; Carnielli, V.P.; Hamvas, A. Metabolic kinetics of pulmonary surfactant in newborn infants using endogenous stable isotope techniques. J. Lipid Res. 46:1257-1265, 2005.

Magkos, F.; Wright, D.C.; Patterson, B.W.; Mohammed, S.; Mittendorfer, B. Lipid metabolism response to a prolonged bout of endurance exercise. Amer. J. Physiol. Endocrinol. Metab. 290:E355-362, 2006.

Klein, S.; Mittendorfer, B.; Eagon, J.C.; Patterson, B.; Grant, L.; Feirt, N.; Seki, E.; Brenner, D.; Korenblat, K.; McCrea, J. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology 130:1564-1572, 2006.

Magkos, F.; Patterson, B.W.; Mittendorfer, B. Reproducibility of stable isotope labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics. J. Lipid Res. 48:1204-1211, 2007.

Breckenridge, S.M.; Raju, B.; Arbelaez, A.M.; Patterson, B.W.; Cooperberg, B.A.; Cryer, P.E. Basal insulin, glucagon and growth hormone replacement. Amer. J. Physiol. Endocrinol. Metab. 293:E1303-1310, 2007.

5. Fabbrini, E.; Mohammed, B.S.; Magkos, F.; Korenblat, K.M.; Patterson, B.W.; Klein, S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134:424-431, 2008.

Department of Medicine
Division of Geriatrics & Nutritional Sciences

Bruce Patterson, Ph.D.