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oVERVIEWPATIENT
CARERESEARCHEDUCATIONFACULTYCONTACTSHOME |
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Faculty Fatiha Nassir,
Ph.D. Contact Information Washington
University School of Medicine Research Interests Dr. Nassir’s research interest is focused on how the combination of nutrition and genetics will result in dyslipidemia and metabolic diseases. She is particularly interested in mechanisms involved in lipid absorption/assembly and regulation of lipoprotein secretion by intestinal and hepatic cells. Dr. Nassir’s current research focuses on the role membrane lipid transporters in the regulation of intestinal and hepatic lipid metabolism. She uses both in vivo and in vitro systems (animal models, cell culture based systems and primary cells) and employs a variety of approaches to study lipid and lipoprotein analysis, gene expression, protein and lipid synthesis, processing and secretion. Education
Post-Doctoral Training
Publications Nauli, AM., Nassir, F., Zheng, S., Q., Lo, C.M., Chun-Min CM., Von Lehmden, SB., Lee, D., Jandacek, RJ., Abumrad, NA and Tso, P - CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. In Press in Gastroenterology (online August 2006). Sha J, McCullough B, Hart E, Nassir F, Davidson NO, Hoover-Plow J. Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen. J Thromb Haemost 2005; 3:2281-2289 Drover, VA., Ajmal, M., Nassir, F., Davidson, NO., Tso, P., Abumrad, NA - CD36 deficiency reduces both intestinal lipid secretion and clearance of chylomicrons from the blood. J. Clin. Invest. 2005: 115:1290-1297. Nassir, F., Xie, Y., Patterson, B.W., Luo, J., Davidson NO - Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor. J. Lipid Res. 2004: 45:1649-1659. Xie, Y., Nassir, F., Luo, J., Buhman, K., Davidson, NO - Intestinal lipoprotein assembly in apobec-1-/- mice reveals subtle alterations in triglyceride secretion coupled with a shift to larger lipoproteins. Am. J. Physiol. Gastrointest Liver Physiol. 2003: 285:G735-746. Nassir, F., Xie, Y., Davidson, NO - Apolipoprotein (a) secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formation. J. Lipid Res. 2003: 44:816-827. Wang, L.C., Nassir, F., Liu, ZY., Ling, L., Kuo, F., Crowell, T., Olson, D., Davidson, NO., Burkly, LC. Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice. Gastroenterology, 2002: 122: 469-482. Nassir, F., Davidson, N.O - Intestinal Apo B48 secretion: a novel surrogate marker of pancreatic exocrine function. Am. J. Gastroenterol. 1999; 94: 3101-3 Nassir F., Bonen, DB, Davidson, N. O - Apolipoprotein (a) synthesis and secretion from hepatoma cells is coupled to triglyceride synthesis and secretion. J. Biol.Chem. 1998: 273: 17793-17800 Bonen, D., Nassir F., Davidson, N. O - Inhibition of N-linked glycosylation results in retention of intracellular apo (a) in hepatoma cells, although nonglycosylated and immature forms of apolipoprotein (a) are competent to associate with apolipoprotein B100 in vivo. J.Lipid Res. 1998: 39: 1629-1640 Nassir, F., Mazur, A., Giannoni, F., Gueux, E., Davidson, N.O., Rayssiguier, Y- Magnesium deficiency modulates hepatic lipogenesis and apolipoprotein gene expression in the rat. Bioch.Biophys.Acta. 1995: 1257:125-132. Nassir, F., Mazur, A., Serougne, C., Gueux, E., Rayssiguier, Y - Hepatic apolipoprotein B synthesis in copper-deficient-rats FEBS- Lett. 1993: 322:33-36. Nassir, F.,
Mazur, A., Felgines, C., Rayssiguier, Y. Age related response to dietary
fructose in the rat: discrepancy in triglyceride and apo B synthesis as
a possible mechanism for fatty liver induction in adult rats. Proc. Soc.
Biol. Med. 1993: 204:180-183.
Department of Medicine
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