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oVERVIEWPATIENT
CARERESEARCHEDUCATIONFACULTYCONTACTSHOME |
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Faculty Bettina Mittendorfer, Ph.D. Research Interests The use of stable isotope labeled tracers for the investigation of metabolism in vivo. Dr. Mittendorfer has applied these methods to investigate whole-body and regional (muscle, leg and splanchnic) lipid, carbohydrate and protein metabolism. Her recent research has focused on the investigation of (i) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (ii) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise. Contact Information Washington University School of Medicine Publications Recent Articles in Peer Review Journals B. Mittendorfer, J.F. Horowitz, S. Klein. Gender differences in lipid and glucose kinetics during short-term fasting. Am J Physiol Endocrinol Metab 281:E1333-1339, 2001. B. Mittendorfer, J.F. Horowitz, S. Klein. Effect of gender on lipid metabolism during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab 283:E58-64, 2002. B. Mittendorfer, B. W. Patterson, S. Klein. Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr. 77:573-579, 2003. B. Mittendorfer, B.W. Patterson, S. Klein, L.S. Sidossis. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effect of sex and obesity. Am J Physiol Endocrinol Metab 284:E708-715, 2003. B. Mittendorfer, J. L. Andersen, P. Plomgaard, B. Saltin, J.A. Babraj, K. Smith, M. J. Rennie. Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. J Physiol 563:203-11, 2005. B.B. Rasmussen, S. Fujita, R.R. Wolfe, B. Mittendorfer, M. Roy, V.L. Rowe, and E. Volpi. Insulin resistance of muscle protein metabolism in aging. FASEB J 20:768-769, 2006. P. Plomgaard, K. Bouzakri, R. Krogh-Madsen, B. Mittendorfer, J. R. Zierath, B. K. Pedersen. TNF-? induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt Substrate 160 phosphorylation. Diabetes 54: 2939-2945, 2005. R. Krogh-Madsen, P. Plomgaard, K. Møller, B. Mittendorfer, B.K. Pedersen. Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans. Am J Physiol Endocrinol Metab 291 E108-E114, 2006. F. Magkos, D.C. Wright, B.W. Patterson, B.S. Mohammed, B. Mittendorfer. Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy, young men. Am J Physiol Endocrinol Metab 290:E355-E362, 2006. F. Magkos, B.W. Patterson, B. Mittendorfer. No effect of menstrual cycle phase on basal very low density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Am J Physiol Endocrinol Metab 291 E1243-E1249, 2006. F. Magkos, B.W. Patterson, S. Klein, B. Mittendorfer. Women produce fewer but TG-richer VLDL than men. J Clin Endocrinol Metab 92:1311-8, 2007. F. Magkos, B.W. Patterson, B.S. Mohammed, B. Mittendorfer. A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men. Am J Physiol Endocrinol Metab 292:E1568-1574, 2007. G.I. Smith, DT. Villareal, B. Mittendorfer. Measurement of human mixed muscle fractional protein synthesis rate depends on the choice of amino acid tracer. Am J Physiol Endocrinol Metab (in press). A. Winther Petersen, F. Magkos, P. Atherton, A. Selby, K. Smith, M.J. Rennie, B.K. Pedersen, B. Mittendorfer. Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab (in press) Recent Book Chapters and Review Articles B. Mittendorfer. Sexual dimorphism in human lipid metabolism. J. Nutr. 135:681-6, 2005. B. Mittendorfer. Insulin resistance: sex matters. Curr. Opin. Clin. Nutr. Metab. Care 8:367-72, 2005 A.R. Coggan, B. Mittendorfer, S. Klein, Methods for quantifying substrate metabolism in humans in Clinical Science: Principles of Translational and Experimental Medicine, D. Schuster & W. Powers (eds), Lippincott Williams & Wilkins, Philadelphia (in press). B. Mittendorfer and S. Klein. Physiological factors that regulate the use of endogenous fat and carbohydrate fuels during endurance exercise. Nutr. Res. Rev. 16:97-108, 2003. B. Mittendorfer and S. Klein. Effect of aging on glucose and lipid metabolism during endurance exercise. Int. J. Sport Nutr. Ex. Metab. 11:S84-89, 2001.
Department of Medicine
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