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oVERVIEWPATIENT
CARERESEARCHEDUCATIONFACULTYCONTACTSHOME |
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Faculty Bettina Mittendorfer, Ph.D. Research Interests and Expertise Dr. Mittendorfer uses stable isotope labeled tracer methods for the investigation of metabolism in vivo (e.g., to evaluate whole-body and regional lipid, carbohydrate and protein metabolism such as hepatic glucose and triglyceride production, muscle protein synthesis rate, etc.). Her recent research has focused on the investigation of (i) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (ii) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise. Contact Information Washington University School of Medicine Publications Recent Articles in Peer Review Journals B. Mittendorfer, J.F. Horowitz, S. Klein. Effect of gender on lipid metabolism during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab 283:E58-64, 2002. B. Mittendorfer, B.W. Patterson, S. Klein. Effect of weight loss on VLDL-TG and apolipoprotein B100 kinetics in obese women. Am J Physiol Endocrinol Metab 284:E549-556, 2003. B. Mittendorfer, B.W. Patterson, S. Klein, L.S. Sidossis. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effect of sex and obesity. Am J Physiol Endocrinol Metab 284:E708-715, 2003. B. Mittendorfer, O. Liem, B. W. Patterson,
J.M. Miles, S. Klein. What does the measurement of whole-body fatty acid
rate of appearance in plasma by using a fatty acid tracer really mean?
Diabetes 52:1641-1648, 2003. B. Mittendorfer, J. L. Andersen, P. Plomgaard, B. Saltin, J.A. Babraj, K. Smith, M. J. Rennie. Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. J Physiol 563:203-11, 2005. P. Plomgaard, K. Bouzakri, R. Krogh-Madsen, B. Mittendorfer, J. R. Zierath, B. K. Pedersen. TNF-? induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt Substrate 160 phosphorylation. Diabetes 54: 2939-2945, 2005. F. Magkos, D.C. Wright, B.W. Patterson, B.S. Mohammed, B. Mittendorfer. Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy, young men. Am J Physiol Endocrinol Metab 290:E355-E362, 2006. F. Magkos, B.W. Patterson, S. Klein, B. Mittendorfer. Women produce fewer but TG-richer VLDL than men. J Clin Endocrinol Metab 92:1311-8, 2007. G.I. Smith, P. Atherton, D.T. Villareal, T.N. Frimel, D. Rankin, M.J. Rennie, B. Mittendorfer. Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS ONE 3:1875-83, 2008. B. Mittendorfer, F. Magkos, E. Fabbrini, B.S. Mohammed, B.W. Patterson, S. Klein. Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity 17:1872-7, 2009. G.I. Smith, P. Atherton, D.N. Reeds, B.S. Mohammed, H. Jaffrey, D. Rankin, M.J. Rennie, B. Mittendorfer. No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in young and middle-aged adults. J Appl Physiol 107:1308-15, 2009 F. Magkos, E. Fabbrini, B.W. Patterson, S. Klein, B. Mittendorfer. Estrogen deficiency after menopause does not result in male VLDL-triglyceride and VLDL-apolipoprotein B-100 metabolism phenotype. J Clin Endocrinol Metab 95:3377-84, 2010. D.T. Villareal, G.I. Smith, D.R. Sinacore, K. Shah, C. Lambert, B. Mittendorfer. Regular multi-component exercise increases physical fitness and muscle protein anabolism in obese, older adults. Obesity (in press). G.I. Smith, P. Atherton, D.N. Reeds, B.S. Mohammed, D. Rankin, M.J. Rennie and B. Mittendorfer. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults. A randomized, controlled trial. Am J Clin Nutr. (In press). Selected Review Articles, Editorials and Book Chapters B. Mittendorfer. Sexual dimorphism in human lipid metabolism. J. Nutr. 135:681-6, 2005. B. Mittendorfer. Insulin resistance: sex matters. Curr. Opin. Clin. Nutr. Metab. Care 8:367-72, 2005 B. Mittendorfer and M.J. Rennie. Swings and roundabouts for muscle gain and loss: differences between sexes? J Appl Physiol 100:375-6, 2006. F. Magkos and B. Mittendorfer. Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo. Clin Lipidol 4:215-230, 2009. F. Magkos, X. Wang and B. Mittendorfer. Metabolic actions of insulin in men and women. Nutrition 26:686-93, 2010.
Department of Medicine
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