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oVERVIEWPATIENT
CARERESEARCHEDUCATIONFACULTYCONTACTSHOME |
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Faculty Bettina Mittendorfer, Ph.D. Research Interests The use of stable isotope labeled tracers for the investigation of metabolism in vivo. Dr. Mittendorfer has applied these methods to investigate whole-body and regional (muscle, leg and splanchnic) lipid, carbohydrate and protein metabolism. Her recent research has focused on the investigation of (i) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (ii) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise. Contact Information Washington University School of Medicine Publications Recent Articles in Peer Review Journals B. Mittendorfer and L. S. Sidossis. Mechanism of short-term high-carbohydrate induced increase in plasma triacylglycerol concentration. Am J Clin Nutr 73:892-899, 2001. B. Mittendorfer, J.F. Horowitz, S. Klein. Gender differences in lipid and glucose kinetics during short-term fasting. Am J Physiol Endocrinol Metab 281:E1333-1339, 2001. B. Mittendorfer, J.F. Horowitz, S. Klein. Effect of gender on lipid metabolism during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab 283:E58-64, 2002. B. Mittendorfer, B.W. Patterson, S. Klein, L.S. Sidossis. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effect of sex and obesity. Am J Physiol Endocrinol Metab 284:E708-715, 2003. B. Mittendorfer, D. A. Fields, S. Klein. Excess body-fat in men decreases plasma fatty acid availability and oxidation during endurance exercise. Am J Physiol Endocrinol Metab 286:E354-362, 2004. P. Plomgaard, K. Bouzakri, R. Krogh-Madsen, B. Mittendorfer, J. R. Zierath, B. K. Pedersen. TNF-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt Substrate 160 phosphorylation. Diabetes 54: 2939-2945, 2005. F. Magkos, B.W. Patterson, S. Klein, B. Mittendorfer. Women produce fewer but TG-richer VLDL than men. J Clin Endocrinol Metab 92:1311-8, 2007. A. Winther Petersen, F. Magkos, P. Atherton, A. Selby, K. Smith, M.J. Rennie, B.K. Pedersen, B. Mittendorfer. Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab 293:E843-8, 2007. G.I. Smith, P. Atherton, D.T. Villareal, T.N. Frimel, D. Rankin, M.J. Rennie, B. Mittendorfer. Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS ONE 3:1875-83, 2008. B. Mittendorfer, F. Magkos, E. Fabbrini, B.S. Mohammed, B.W. Patterson, S. Klein. Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity (in press) G.I. Smith, P. Atherton, D.N. Reeds, B.S. Mohammed, H. Jaffrey, D. Rankin, M.J. Rennie, B. Mittendorfer. No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in young and middle-aged adults. J Appl Physiol (in press) Selected Review Articles, Editorials and Book Chapters B. Mittendorfer. Sexual dimorphism in human lipid metabolism. J. Nutr. 135:681-6, 2005. B. Mittendorfer. Insulin resistance: sex matters. Curr. Opin. Clin. Nutr. Metab. Care 8:367-72, 2005 A.R. Coggan, B. Mittendorfer, S. Klein, Methods for quantifying substrate metabolism in humans in Clinical Science: Principles of Translational and Experimental Medicine, D. Schuster & W. Powers (eds), Lippincott Williams & Wilkins, Philadelphia, 2005 B. Mittendorfer and L.R. Peterson. Cardiovascular consequences of obesity. Drug Discovery Today: Therapeutic Strategies 5:53-61, 2008. F. Magkos and B. Mittendorfer. Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo. Clin Lipidol 4:215-230, 2009. F. Magkos and B. Mittendorfer. Gender differences in lipid metabolism and the effect of obesity. Obstetrics and Gynecology Clinics of North America. 36(2):245-65, 2009.
Department of Medicine
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