Faculty

Samuel Klein, M.D.
William H. Danforth Professor of Medicine and Nutritional Science Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Medical Director, Weight Management Program

Research Interests

Dr. Klein’s research activities involve the use of stable isotope tracers to study the regulation of substrate metabolism in humans in vivo. His laboratory is particularly interested in the pathophysiology of lipid metabolism in obesity.

Contact Information

Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8031
St. Louis, MO 63110-1093
Phone: (314) 362-8708
Fax: (314) 362-8230
E-mail: sklein@dom.wustl.edu

Publications

Recent Articles in Peer Review Journals

Weerasooriya V, Rennie MJ, Anant S, Alpers DH, Patterson BW, Klein S. Dietary fiber decreases colonic epithelial cell proliferation and protein synthetic rates in human subjects. Am J Physiol Endocrinol Metab 290:E1104-E1108, 2006.

Klein S, Mittendorfer B, Eagon JC, Grant L, Seki E, Brenner D, Feirt N, Korenblat K, Patterson B, McCrea J. Gastric bypass surgery-induced weight loss improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology 130:1564-1572, 2006.

Reeds DN, Yarasheski KE, L Fontana L, Cade WT, Laciny E, Demoss A, Patterson BW, Powderly WG, Klein S. Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. Am J Physiol Endocrinol Metab 290:E47-E53, 2006.

Villareal DT, Miller BV, Banks M, Fontana L, Sinacore DR, Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr 84:1317-1323, 2006.

Sullivan S, Klein S. Effect of a short-term Pritikin diet therapy on the metabolic syndrome. J Cardiometab Syndr 1:308-312, 2006.

Reeds DN, Stuart CA, Perez O, Klein S. Adipose tissue, hepatic and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans. Metabolism 55:1658-1663, 2006.

Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Human gut microbes associated with obesity. Nature 444:1022-1023, 2006.

Fontana L, Eagon JC, Colonna M, Klein S. Impaired mononuclear cell immune function in obesity is corrected by weight loss. Rejuv Res 10:41-46, 2007.

Coughlin CC, Finck BN, Eagon JC, Halpin VJ, Magkos F, Mohammed BS, Klein S. Effect of marked weight loss on adiponectin gene expression and plasma concentrations. Obesity 15:640-645, 2007.

Sullivan S, Cloninger CR, Przybeck TR, Klein S. Personality characteristics in obesity and relationship with successful weight loss. Int J Obes 31:669-674, 2007.

Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in extremely obese humans. Diabetes 56:1010-1013, 2007.

Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134:424-431, 2008.

Villareal DT, Banks M, Patterson BW, Polonsky K, Klein S. Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity 16:1349-1354, 2008.

Korenblat K, Fabbrini E, Mohammed BS, Klein S. Liver, skeletal muscle and adipose tissue insulin resistance is directly related to intrahepatic triglyceride content in obese men and women. Gastroenterology 134:1369-1375, 2008.

Department of Medicine
Division of Geriatrics & Nutritional Sciences

Samuel Klein, MD