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Faculty John O. Holloszy, M.D. Research Interests Dr. Holloszy’s current research runs along two lines: Biochemical and Anatomical Adaptions to Exercise: Caloric Restriction and Aging in Humans: Contact Information Washington University School of Medicine Publications Recent Articles in Peer Review Journals Garcia-Roves P, Huss JM, Han DH, Hancock CR, Iglesias-Gutierrez E, Chen M, Holloszy JO. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. PNAS 104:10709-10713, 2007. Hancock CR, Han DH, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO. High fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc. Natl. Acad. Sci. 105:7815-7820, 2008. Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 7:681-687, 2008. Holloszy JO. Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J. Physiol. Pharmacol. 59(Suppl 7):5-18, 2008 Holloszy JO. Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance. Am. J. Clin. Nutr. 89:463S-466S, 2009. Hawley JA, Holloszy JO. Exercise: it’s the real thing! Nutr. Rev. 67:172-178, 2009. Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am. J. Clin. Nutr. 89:1459-1467, 2009 Kirwan JP, Solomon TP, Wojta DM, Slaten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 297:E151-E156, 2009. Han DH, Hancock CR, Jung SR, Holloszy JO. Is “fat-induced” muscle insulin resistance rapidly reversible? Am. J. Physiol. Endocrinol. Metab., 297:E236-E241, 2009. Fontana L, Klein S, Holloszy JO. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age 32:97-108, 2010. Cangemi R, Friedmann, AJ, Holloszy JO, Fontana L. Long-term effects of calorie restriction on serum sex-hormone concentrations in men. Aging Cell 9:236-242, 2010. Hancock CR, Han DH, Higashida K, Kim SH, Holloszy JO. Does calorie restriction induce mitochondrial biogenesis? A reevaluation. FASEB J. 2010 Nov 4. [Epub ahead of print]
Department of Medicine
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