Luigi Fontana, M.D., Ph.D.
Trained in both internal medicine and metabolism, Fontana has an interest in nutrition, aging and longevity. His research focuses on the potential role of diet and exercise in retarding the aging process. He is investigating the effects of severe calorie restriction, plant-based diets and endurance exercise on outcomes such as cardiovascular risk factors and function, inflammation, immune function, glucose tolerance, bone metabolism and quality of life. He is also studying the endocrine role of abdominal fat storage as a mediator of insulin resistance and accelerated aging.
Washington University School of Medicine
Recent Articles in Peer Review Journals
Fontana L, Giagulli C, Minuz P, Lechi A, Laudanna C. 8-iso-PGF2a induces b2 integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury. Arteriosclerosis, Thrombosis, and Vascular Biology 2001;21:55-60.
Fontana L, Giagulli C, Cominacini L, Fratta Pasini A, Minuz P, Lechi A, Sala A, Laudanna C. Integrin-dependent neutrophil adhesion induced by minimally modified low density lipoproteins is mediated by F2-isoprostanes. Circulation 2002;106:2434-2441.
Fontana L, Meyer T.E., Klein S, Holloszy J.O. Long-Term Calorie Restriction Is Highly Effective In Reducing The Risk For Atherosclerosis In Humans. Procedings of the National Academy of Science USA 2004;101(17):6659-6663.
Klein S, Fontana L, Young VL, Coggan AR, Kilo C, Patterson BW, Mohammed BS. Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease. New England Journal of Medicine 2004; 350(25):2549-57.
Fontana L, Shew J.S., Holloszy J.O., Villareal D. Low Bone Mass in Subjects on a Long-term Raw Vegetarian Diet. Archives of Internal Medicine 2005;165:684-689.
Reeds D.N., Yarasheski K.E., Fontana L, Cade W.T., Patterson B.W., Demoss A, Laciny E, Powderly W.G., Klein S. Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. American Journal of Physiology Endocrinology and Metabolism 2006;290(1):E47-E53.
Meyer T.E., Kovács S.J., Ehsani A.A., Klein S, Holloszy J.O., Fontana L. Long-term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. Journal of American Collage Cardiology 2006; 47(2):398-402.
Fontana L. Excessive adiposity, calorie restriction and aging. JAMA 2006; 295(13):1577-1578.
Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, Fontana L, Klein S, Holloszy JO, and The Washington University School of Medicine CALERIE Group. One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adipose Tissue. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2006 61: 943-950.
Fontana L, Klein S, Holloszy J.O, Premachandra B.N. Effect of Long-term Calorie Restriction with Adequate Protein and Micronutrients on Thyroid Hormones. Journal of Clinical Endocrinology & Metabolism 2006;91:3232-3235.
Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. American Journal of Clinical Nutrition 2006;84:1033–42.
Villareal DT, Miller III BV, Banks M, Fontana L, Sinacore DR, Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. American Journal of Clinical Nutrition 2006; 84:1317–23.
Fontana L, Klein S, Holloszy J.O. Long-term low-protein low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. American Journal of Clinical Nutrition 2006;84:1456–62.
Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO, and the WUSM CALERIE Group. Bone Mineral Density Response to Caloric Restriction-Induced Weight Loss or Exercise-Induced Weight Loss: a Randomized Controlled Trial. Archives of Internal Medicine 2006;166(22):2502-10.
Fontana L, Eagon JC, Colonna M, Klein S. Impaired mononuclear cell function in extreme obesity is corrected by weight loss. Rejuvenation Research 2007;10(1):41-46.
Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO. The effects of weight loss by exercise or caloric restriction on lower extremity muscle size and strength and aerobic capacity. Journal of Applied Physiology 2007;102: 634–640.
Fontana L, Klein S. Aging, adiposity and calorie restriction. JAMA 2007;297(9):986-994.
Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007;56:1010-1013.
Fontana L, Meyer T.E., Klein S, Shew J, Holloszy J.O. Long-term low-calorie low-protein diet and endurance exercise are associated with low cardiometabolic risk. Rejuvenation Research 2007;10(2):225-34.
Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO. Calorie Restriction or Exercise: Effects on Coronary Heart Disease Risk Factors. A Randomized Controlled Trial. American Journal of Physiology Endocrinology and Metabolism 2007;293(1):E197-202
Holloszy JO, Fontana L. Calorie restriction in humans: an update. Experimental Gerontology 2007;42(8):709-12.
Fontana L. Calorie restriction and cardiometabolic health. European Journal of Cardiovascular Prevention and Rehabilitation 2007 (in press).
Fontana L. Nutrition, Adiposity and Health. Epidemiol Prev 2007; 31(5):290-294.
Early DS, Fontana L, Davidson NO. Translational approaches to addressing complex genetic pathways in colorectal cancer. Translational Research 2008;151:10–16.
Department of Medicine