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oVERVIEWPATIENT
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Faculty Nada A. Abumrad, Ph.D The research of Dr Abumrad’s group deals with the molecular mechanisms regulating utilization of fatty acids and how abnormalities in fatty acid metabolism can result in metabolic disease such as obesity and diabetes. She identified the plasma membrane protein CD36 as a facilitator of cellular fatty acid uptake and is now examining the role of CD36 in modulating tissue adaptation to nutrient fluctuations and other stresses. Mice models of tissue-specific variations in CD36 gene level are being studied but the goal is to translate findings in rodents to humans where polymorphisms in the CD36 gene are common. A current project in humans is exploring (in collaboration with Alan Permutt and Sam Klein) whether mutations in CD36 are associated with an increased risk of insulin resistance and diabetes. Contact Information Washington University School of Medicine Publications Recent Articles in Peer Review Journals Abumrad
NA. CD36 may determine our desire for dietary fats. Bastie C, Nahle Z, McLoughlin T, Esser K, Zhang W, Unterman T, Abumrad NA. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and independent mechanisms. J Biol Chem, 280:14222-9, 2005. Drover VA, Ajmal M, Nassir F, Davidson NO, Nauli AM, Tso P and Abumrad. NA. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest, 115:1290-7, 2005. Noushmehr H, D'Amico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, Perfetti R. Fatty Acid Translocase (FAT/CD36) Is Localized on Insulin-Containing Granules in Human Pancreatic {beta}-Cells and Mediates Fatty Acid Effects on Insulin Secretion. Diabetes, 54:472-81, 2005. Héron-Milhavet L, Haluzik M, Ibrahimi A, Yakar S, Kim1 H, Yau D, Asghar Z, Joseph J, Wheeler M, Abumrad NA and LeRoith D. Muscle-Specific Overexpression Of Cd36 Reverses The Insulin Resistance And Diabetes Of Mkr Mice. Endocrinology, 145:4667-76, 2004. Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, Iori E, Lager RA, Shrof AR, Gervino EV, Johnstone MT, Abumrad NA, Avogaro A, Trischitta V, and Doria A. A Common Haplotype at the CD36 Locus Is Associated With High FFA Levels and Increased Cardiovascular Risk in Caucasians. Human Molecular Genetics, 13:2197-205, 2004. Bastie C, Hajri T, Drover V, Grimaldi P and Abumrad NA. CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness. Diabetes. 53:2209-16, 2004. Irie
H, Krukenkamp IB, Brinkmann JF, Gaudette GR, Saltman AE, Jou W, Glatz
JF, Abumrad NA, Ibrahimi A.Myocardial recovery from ischemia
is impaired in CD36-null mice and restored by myocyte CD36 expression
or medium-chain fatty acids. Proc Natl Acad Sci U S A.;100:6819-24, 2003.
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