Faculty

Xiong Su, Ph.D.
Research Assistant Professor in Medicine

Research Interests

Dr. Su’s laboratory examines molecular mechanisms mediating insulin signaling and lipid metabolism in metabolic diseases. A lipidomic approach using electrospray ionization mass spectrometry (ESI/MS) is employed to identify and quantify lipid molecular species from organic extracts of biological samples. In conjunction with molecular biological approaches and transgenic mouse models, chemical mechanisms of obesity-related dysfunction of insulin signaling and lipid metabolism are studied. Dr. Su is also interested in understanding molecular mechanisms mediating ubiquitination, trafficking and degradation of proteins involved in lipid trafficking and metabolism (e.g. CD36).

Contact Information

Washington University School of Medicine
Division of Geriatrics and Nutritional Science
660 S. Euclid Avenue, Box 8031
St. Louis, MO 63110
Phone: (314) 362-8352
email: xsu@dom.wustl.edu

Publications

Recent Articles in Peer Review Journals

Select Recent Publications:
1. Su, X., Mancuso, D. J., Bickel, P. E., Jenkins, C. M., and Gross, R. W. (2004) Small Interfering RNA Knockdown of Calcium-independent Phospholipases A2 b or g Inhibits the Hormone-induced Differentiation of 3T3-L1 preadipocytes. J. Biol. Chem., 279, 21740-21748
2. Su, X., Han, X., Yang, J., Mancuso, D. J., Chen, J., Bickel, P.E., and Gross, R.W. (2004) Sequential Ordered Fatty Acid a Oxidation and D9 Desaturation Are Major Determinants of Lipid Storage and Utilization in Differentiating Adipocytes. Biochemistry, 43, 5033-5044
3. Su, X., Han, X., Mancuso, D. J., Abendschein, D. R., and Gross, R.W. (2005) Accumulation of Long Chain Acylcarnitine and b-Hydroxy Acylcarnitine Molecular Species in Diabetic Myocardium: Identification of Alterations in Mitochondrial Fatty Acid Processing in Diabetic Myocardium by Shotgun Lipidomics. Biochemistry, 44, 5234-5245
4. Su, X., Lodhi, I. J., Saltiel, A. R., and Stahl, P. D. (2006) Insulin-stimulated interaction between insulin receptor substrate 1 and p85a and activation of protein kinase B/AKT require RAB5. J. Biol. Chem., 281, 27982-27990
5. Hodzic, D., Kong, C., Wainszelbaum, M. J., Charron, A. J., Su, X., and Stahl, P. D. (2006) TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. Genomics, 88, 731-736
6. Li, Y. L., Su, X., Stahl, P. D., and Gross, M. L. (2007) Quantification of Diacylglycerol Molecular Species in Biological Samples by Electrospray Ionization Mass Spectrometry after One-step Derivatization. Anal. Chem., 79, 1569-1574
7. Kong, C., Su, X., Chen, P.-I., and Stahl, P. D. (2007) Rin1 Interacts with STAM and Mediates Epidermal Growth Factor Receptor Trafficking and Degradation. J. Biol. Chem., 282, 15294-15301
8. Su, X., Kong, C., and Stahl, P. D. (2007) GAPex-5 Mediates Epidermal Growth Factor Receptor Ubiquitination, Trafficking and Degradation. J. Biol. Chem., 282, 21278-21284

Department of Medicine
Division of Geriatrics & Nutritional Sciences